Publications

2017

Huang, C., Xiao, X., Yang, Y., Mishra, A., Liang, Y., Zeng, X., Yang, X., Xu D., Blackburn, M. R., Henke, C. A., and Liu, L.(2017) MicroRNA-101 attenuates pulmonary fibrosis by inhibiting fibroblast proliferation and activation J. Biol. Chem. 292:16420-16439. PMCID: PMC5633105

Wang, X., Wu, W., Zhang, W., Booth, J. L., Duggan, E. S., Tian, L., More, S., Zhao, Y. D., Sawh, R., N., Liu, L., Zou, M., and Metcalf, J. P. (2017) RIG-I overexpression decreases mortality of cigarette smoke exposed mice during influenza A virus infection. Respir. Res. 18:166.

Premaratne, G., Al Mubarak, Z., Senavirathna, K. S., Liu, L. and Krishnan, S. (2017) Measuring ultra-low levels of nucleotide biomarkers using quartz crystal microbalance and SPR microarray imaging methods: a comparative analysis. Sensors & Actuators: B. Chemical. 253:368-375.

Wang, L., Fu, B,  Li, W., Patil, G., Liu, L., Dorf, M. E., and Li, S (2017). Comparative influenza protein interactomes reveal the role of PKP2 in perturbation of viral polymerase complex. Nature Commun. 8:13876.

Zeng*, X., Huang*, C., Senavirthna, L. K., Wang, P., and Liu, L. (2017) miR-27b inhibits fibroblast activation via targeting TGFβ signaling pathway. BMC Cell Biol. 18:9 (*co-first author). PMCID: PMC5240426.

2016

Mishra, A., Guo, Y., Zhang, L., More, S., Weng, T., Chinatagari, N. R., Huang, C., Liang, Y., Pushparaj, S., Gou, D., Breshears, M. and Liu, L. (2016) A critical role of P2X7 receptor-induced VCAM-1 shedding and neutrophil infiltration during acute lung injury. J. Immunol. 197: 2828-2837. PMCID: PMC5026933

Xiao, X., Senavirathna, L., K., Gou, X., Huang, C., Liang, Y. and Liu, L. (2016) EZH2 enhances the differentiation of fibroblasts to myofibroblasts in idiopathic pulmonary fibrosis. Physiol. Rep. 4:e12915. (Editor’s Choice)

Qiu, H. L., Liu, N., Luo, L., Zhong, J. H., Tang, Z. X., Kang, K., Qu, J. L., Liu, L., Li, L., and Gou, D. (2016) MicroRNA-17-92 regulates myoblast proliferation and differentiation by targeting the ENH1/Id1 signaling axis, Cell Death and Differ, 23:1658-69.

2015

Zhang, L., Huang, C., Guo, Y., Gou, X., Hinsdale, H., Lloyd, P., and Liu, L.(2015) miR-26b modulates NF-kB pathway by regulating PTEN in bovine alveolar macrophages challenged with lipopolysaccharide. J. Immunol. 195:5404-5414.

Niu, Y., Zhang, L., Qiu, H., Wu, Y., Wang, Z., Zai, Y., Liu, L., Qu, J., Kang, K., and Gou, D. (2015) An improved method for detecting circulating microRNA with S-Poly(T) Plus real-time PCR. Sci Rep. in press.

Guo, Y., Mishra, A., Howland, E., Zhao, C., Shukla, D., Weng, T. and Liu, L. (2015) Platelet-derived Wnt antagonist dickkop-1 is implicated in ICAM-1/VCAM-1-mediated neutrophilic acute pulmonary inflammation. Blood 126:2220-2229.

Huang, C., Yang, Y., and Liu, L. (2015) Interaction of lncRNAs and microRNAs in the pathogenesis of Idiopathic Pulmonary Fibrosis. Physiol. Genomics. 47:463-469.

Wang*, Y., Huang*, C., Chintagari, N. R., Xi, D., Weng, T., and Liu, L. (2015) miR-124 regulates fetal pulmonary epithelial maturation by targeting NFIB. Am. J. Physiol. Lung Cell. Mol. Physiol. 309:L400-L413. (*co-first author).

Mubarak, Z. H., Ramesh, R., Liu, L., and Krishnan, S. (2015) Surface Plasmon Resonance Imaging of Gold-Small Molecule Interactions Is Influenced by Refractive Index and Chemical Structures. Journal of Colloid & Interface Science. 460:209-213.

Zeng, Y., Wang, Y., Wu, Z., Kang, K., Peng, X., Qu, J., Liu, L., Usha Raj, J.U., and Gou, D. (2015) MicroRNA-9 enhances the transactivation of nuclear factor of activated T cells by targeting KPNB1 and Dyrk1B. Am. J. Physiol. Cell Physiol. 308: C720–C728.

Xiao X., Huang, C., Zhao, C., Gou, X., Senavirathna, L. K., Hinsdale, M., Lloyd, P. and Liu, L. (2015) Regulation of myofibroblast differentiation by miR-424 during epithelial-to-mesenchymal transition. Arch. Biochem. Biophys. 566: 49-57. PMCID: PMC4297572.

Zhang, H., Guo, Y., Mishra, A., Gou, D., Chintagari, N.R., and Liu, L. (2015) miR-206 regulates lung surfactant secretion by targeting VAMP-2. FEBS Letter, 589: 172-176. PMCID: PMC4281256.

Narasaraju*, T., Shukla*, D. More, S., Huang, C. Zhang, L., Xiao, X., Liu, L. (2015) Role of miR-150 and glycoprotein non-metastatic melanoma protein B in hyperoxia-induced neonatal lung injury. Am. J. Respir. Mol. Cell. Biol. 52: 253-261 (*co-first author). PMCID:PMC4370241.

2014

Zeng, H., Shu, W.Q., Chen, J.Q, Liu, L., Wang, D.H., Fu, W.J., Wang, L.Q., Luo, J.H., Zhang, L., Tan, Y., Qiu, Z.Q. and Huang, Y.J. (2014) Experimental comparison of the reproductive outcomes and early development of the offspring of rats given five common types of drinking water. PLoS ONE 9: e108955.

Wu, W, Zhang, W., More, S., Booth, J. L., Duggan, E. S., Liu, L., Zhao, Y. D., and Metcalf, J. P. (2014) Cigarette smoke attenuates the RIG-I-initiated innate antiviral response to influenza infection in two murine models. Am. J. Physiol. Lung Cell. Mol. Physiol. 307:L848-L858. PMCID: PMC4254961.

Huang, C., Xiao, X., Chintagari, N. R., Breshears, M., Wang, Y. and Liu, L. (2014) microRNA and mRNA expression profiling in rat acute respiratory distress syndrome. BMC Medical Genomics, 7:46. PMCID: PMC4128536.

Guo, Y., Mishra, A., Weng, T., Chintagari, N. R., Wang, Y., Zhao, C., Huang, C., and Liu, L. (2014) Wnt3a mitigates acute lung injury by reducing P2X7 receptor-mediated alveolar epithelial type I cell death. Cell Death Dis. 5, e1286.

Liu, L., Lloyd, P., and Hinsdale, M. (2014) Lung Development (Chapter 15) in “MicroRNA in Regenerative Medicine” (book chapter, Sen, C. eds, Academic Press), p381-399.

2013

Kang, K., Peng, X.,  Zhang, X.,  Wang, Y., Zhang, L., Gao, L., Weng, T., Zhang, H., Ramchandran, R., Raj, J. U., Gou, D., and Liu, L. (2013) MicroRNA-124 suppresses the transactivation of nuclear factor of activated T cells by targeting multiple genes and inhibits the proliferation of pulmonary artery smooth muscle cells. J. Biol. Chem. 288:25414-25427. PMCID: PMC3757204.

Wang Y., Huang, C., Chintagari, N. R., Bhaskaran, M., Huang, C., Weng, T., Guo, Y. and Liu, L. (2013) miR-375 regulates alveolar epithelial cell trans-differentiation by inhibiting Wnt/β-catenin pathway. Nucleic. Acids Res. 41:3833-44. PMCID: PMC3616718.

Luo, J., Zhao, Q., Zhang, L., Qiu, Z., Liu, L., Chen, J., Zeng, H., Huang, Y., Tan, Y., Yang, L., Zhang, Y., Yang, X., Liu, W., Wang, L., and Shu, W. (2013) The consumption of low-mineral bottled water increases the risk of cardiovascular disease: An experimental study of rabbits and young men. Int J. Cardiol. 168:4454-4456.

2012

Bhaskaran, M., Xi, D., Wang, Y., Huang, C. Narasaraju, T., Shu, W.,  Zhao, C. Xiao, X., More, S., Breshears, M. and Liu, L. (2012) Identification of microRNAs changed in the neonatal lungs in response to hyperoxia exposure. Physiol. Genomics 44:970-980. PMCID: PMC3472467.

Weng, T., Mishra, A., Guo, Y., Wang, Y., Su, L. Huang, C., Zhao, C., Xiao, X. and Liu, L. (2012) Regulation of surfactant secretion by miR-150. Biochem. Biophys. Res. Commun. 422:586-589. PMCID: PMC3377846.

Wang, P., Howard, M.D., Zhang, H., Chintagari, N. R., Bell, A., Jin, N., Mishra, A., and Liu, L. (2012) Characterization of VAMP-2 in the lung: implication in lung surfactant secretion. Cell Biol. Intl. 36: 785-791. PMCID: PMC3434271.

Chintagari, N. R. and Liu, L. (2012) GABA receptor ameliorates ventilator-induced lung injury in rats by improving alveolar fluid clearance. Critical Care 16:R55. PMCID: PMC3681384.

Zhao, C., Huang, C., Weng, T., Xiao, X., Ma, H., Liu, L. (2012) Computational prediction of microRNAs targeting GABA receptors and experimental verification of miR-181, miR-216 and miR-203 targets in GABA-A receptor. BMC Res Notes. 5:91. PMCID: PMC 3296612.

2011

Mishra, A., Chintagari, N. R., Guo, Y., Weng, T., Su, L., and Liu, L. (2011) Purinergic P2X7 receptor regulates lung surfactant secretion in a paracrine manner. J. Cell Sci. 124:657-668. PMCID: PMC 3031375.

2010

Chintagari, N. R., Jin, N., Gao, L., Wang, Y., Xi, D., and Liu, L. (2010) Role of GABA receptors in fetal lung development in rats. PLoS One. 5:e14171. PMCID: PMC2994757.

Weng, T. and Liu, L.  (2010) The Role of pleiotrophin and β-catenin in fetal lung development. Respir Res 11:80. PMCID: PMC 2901351.

Chintagari, N. R., Mishra, A., Su, L., Ayalew, S., Hartson, H. and Liu, L. (2010) Vacuolar ATPase regulates surfactant secretion in rat alveolar type II cells by modulating lamellar body calcium. PLoS One 5: e9228. PMCID: PMC 2821907.

Zhang, H., Mishra, A., Chintagari, N. R., Gou, D. and Liu, L. (2010) MicroRNA-375 inhibits lung surfactant secretion by altering cytoskeleton reorganization. IUBMB Life. 62:78-83. PMCID: PMC 2806485.

2009

Weng, T., Gao, L., Bhaskaran, M., Guo, Y., Gou, D., Narayanaperumal, J., Chintagari, N. R., Zhang, K. and Liu, L. (2009) Pleiotrophin regulates lung epithelial cell proliferation and differentiation via β-catenin and Dlk1. J. Biol. Chem. 284: 28021-28032. PMCID: PMC 2788854.

Yang, C. X., Su, L., Wang, Y., and Liu, L. (2009) UTP regulation of ion transport in alveolar epithelial cells involves distinct mechanisms. Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L439-L454. PMCID: PMC 2739774.

Bhaskaran*, M., Wang*, Y., Zhang, H., Weng, T., Baviskar, P., Guo, Y., Gou, D. and Liu, L. (2009) MicroRNA-127 modulates fetal lung development. Physiol. Genomics. 37:268-278. PMCID: PMC 2685501 (*co-first author) (selected for highlighting in the newsletter of the journal Physiological Genomics. only one article is chosen each month; Highlights from the Literature in Physiology 24:206, 2009).

2008

Gou, D., Mishra, A., Weng, T., Su, L., Chintagari, N. R., Wang, Z.,  Zhang, H., Gao, L, Wang, P., Stricker, H. M. and Liu, L. (2008) Annexin A2 interactions with Rab14 in alveolar type II cells. J. Biol. Chem. 283: 13156-13164. PMCID: PMC 2442313.

Posey, T., Weng, T., Chen, Z., Chintagari, N.R., Wang, P., Jin, N., Stricker, H. and Liu, L. (2008) Arsenic-induced changes in the gene expression of lung epithelial L2 Cells: implications in carcinogenesis. BMC Genomics 9:115. PMCID: PMC 22922705.

Wang, P., Chintagari, N. R., Narayanaperumal, J., Ayalew, S., Hartson, H., and Liu, L. (2008) Proteomic analysis of lamellar bodies isolated from rat lung. BMC Cell Biol. 9:34. PMCID: PMC2459160. (Faculty of 1000 Biology: evaluations for Wang P et al BMC Cell Biol 2008 9 :34 http://www.f1000biology.com/article/id/1120385/evaluation).

Jin, N., Guo, Y., Sun, P., Bell, A., Chintagari, N. R., Bhaskaran, M., Rains, K., Baviskar, P., Chen. Z., Weng, T., and Liu, L. (2008) Ionotropic GABA receptor expression in the lung during development. Gene Exp. Pattn. 8:397-403. PMCID: PMC2581461.

Chintagari, N. R., Gou, D. and Liu, L. (2008) Knockdown of flotillin-2 inhibits lung surfactant secretion by alveolar type 2 cells. Cell Res. 18:701-703. PMCID: 2430057.

2007

Gou, D., Zhang, H., Baviskar, P. S. and Liu, L. (2007) Primer extension-based method for the generation of a siRNA/miRNA. Physiol. Genomics. 31: 554-562.

Chen. Z., Chintagari, N.R., Guo, Y., Bhaskaran, M., Chen, J. W., Gao, L., Jin, N., Weng, T. and Liu, L. (2007) Gene expression profiles of rat alveolar type II cells during hyperoxia exposure and early recovery. Free Radic. Biol. Med. 43: 628-642. PMCID: PMC 2075096

Wang, P., Chintagari, N.R., Gou, D., Su, L. and Liu, L. (2007) Physical and functional interactions of SNAP-23 with Annexin A2. Am. J. Respir. Cell Mol. Biol. 37: 467-476. PMCID: PMC 2176122.

Wang, Y., Weng, T., Gou, D., Chen, Z., Chintagari, N.R.  and Liu, L. (2007) Identification of rat lung-specific microRNAs by microRNA microarray: valuable discoveries for the facilitation of lung research. BMC Genomics. 8:29. PMCID: PMC1790902.

Bhaskaran, M., Kolliputi, N., Wang, Y., Gou, D., Chintagari, N. R. and Liu, L. (2007) Trans-differentiation of alveolar epithelial type II cells to type I cells involves autocrine signaling by TGF-β1 through the smad pathway, J. Biol. Chem. 282:3968-3976.

Gou, D., Weng, T., Wang, Y., Wang, Z., Zhang, H., Gao, L., Chen, Z., Wang, P. and Liu, L. (2007) A new approach for the construction of multiple shRNA expression vectors. J. Gene Med. 9:751-763. (Featured in this issue, http://www3.interscience.wiley.com/cgi-bin/fulltext/115805811/HTMLSTART)

Wang, Y., Stricker, H., Gou, D. and Liu, L. (2007) MicroRNA: past and present. Front. Biosci, 12: 2316-2329.

2006

Jin, N., Kolliputi, N., Gou, D., Weng, T. and Liu, L (2006). A novel function of ionotropic γ-aminobutyric acids receptors involving alveolar fluid homeostasis. J. Biol. Chem, 281:36012-36021.

Weng, T., Chen, Z., Jin, N., Gao, L. and Liu, L. (2006) Gene expression profiling identifies regulatory pathways involved in the late stage of rat lung development. Am. J. Physiol. Lung Cell. Mol. Physiol. 191:L1027-L1037.

Chen*, J. W., Chen*, Z. Chintagari, N. R., Bhaskaran, M., Jin, N., Narasaraju, T. A. and Liu, L.  (2006) Alveolar type I cells protect lung epithelium from oxidative injury. J. Physiol. 572: 625-638. PMCID: PMC177994 (see comment for this paper,
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dop...)
(see press release for this paper: http://www.eurekalert.org/pub_releases/2006-05/bpl-ati050506.php). (*co-first author).

Jin, N. He, K. and Liu, L. (2006) qPCR-DAMS: a database tool to analyze, manage, and store both relative and absolute real time PCR data. Physiol. Genomics, 25:525-527.

Chintagari, N. R., Jin, N., Wang, P., Narasaraju, T., Chen, J. and  Liu, L. (2006) Effect of cholesterol on the exocytosis of alveolar type II cells. Am. J. Respir. Cell. Mol. Biol. 34: 677-687. PMCID: PMC2644229.

Chen, Z., Chen, J. W., Weng, T., Jin. N. and Liu, L. (2006) Identification of rat lung-prominent genes by a parallel DNA microarray hybridization. BMC Genomics, 7:47. PMCID: PMC1523215.

2005

Narasaraju, T. A., Chen, H., Weng, T., Bhaskavan, M., Jin, N., Chen, J. W., Chen, Z., Chinoy, M. and Liu, L. (2005) Expression profile of IGF system during lung injury and recovery in rats exposed to hyperoxia – a possible role of IGF-1 in alveolar epithelial cell proliferation and differentiation. J. Cell Biochem. 97:984-998.

Bhaskaran, M., Chen, H., Chen, Z. and Liu, L. (2005) Hemoglobin is expressed in alveolar epithelial type II cells. Biochem. Biophys. Res Commun. 333:1348-1352.

Jin, N., Narasaraju, T., Kolliputi, N., Chen, J.W. and Liu, L, (2005) Differential expression of GABAA receptor π subunit in cultured rat alveolar epithelial cells. Cell Tissue Res. 321:173-183.

Weng, T., Jin, N. and Liu, L. (2005) Differentiation between amplicon polymerization and non-specific products in SYBR green I real-time polymerase chain reaction. Anal Biochem. 342:167-169.

Maiti, S., Dutta, S. M., Baker, S. M., Zhang J., Narasaraju, T., Liu, L. and Chen, G. P. (2005) In vivo and In vitro oxidative regulation of rat aryl sulfotransferase IV (AST IV). J. Biochem. Mol.Toxicol. 19:109-118.

Chen, Z. and Liu, L. (2005) RealSpot: Software for annotating the quality of DNA microarray raw data and spot images. Physiol Genomics.  21:284-291

2004

Gou*, D. M., Narasaraju*, T. A., Narendranath C. R., Jin, N., Wang, P. and Liu, L. (2004) Gene silencing in alveolar epithelial type II cells using cell-specific promoter in vitro and in vivo.  Nucleic. Acids Res, 32:e134. PMCID: PMC521678 (This paper was listed as a NAR hot paper, http://www3.oup.co.uk/jnls/list/nar/special/11/default.html) (*co-first author).

Chen, Z., Jin, N., Narasaraju, T. A., Chen, J. W., McFarland L. R., Scott, M. and Liu, L. (2004) Identification of two novel markers for alveolar epithelial type I and type II cells. Biochem. Biophys. Res. Commun. 319: 774-780.

Gou, D. M., Wang, P., Jin, N. and Liu, L. (2004) Silencing of annexin II gene in primary culture of alveolar epithelial cells type II cells by RNA interference. Annexins 1:31-38

Abonyo, B., Gou, D. M., Wang, P., Narasaraju, T. A., Wang, Z. X.  and Liu, L.  (2004) Syntaxin 2 and SNAP-23 are required for regulated surfactant secretion. Biochemistry, 43: 3499-3506.

Chen, J. W., Chen, Z., Narasaraju, T. A., Jin, N. and Liu, L. (2004) Isolation of highly pure alveolar epithelial type I and type II cells from rat lungs. Lab Invest. 84:727-735. (This paper was selected as a key feature article for "Inside Lab Invest". see comment: [url=http://www.nature.com/cgi-taf/DynaPage.taf?file=/labinvest/journal/v84/n...)

Singh, T. K., Abonyo, B., Narasaraju T. and Liu, L. (2004) Reorganization of cytoskeleton in alveolar type II cells, a role of annexin II. Cell. Signal. 16:63-70.

2003

Chattopadyay, S., Sun, P., Wang, P., Abonyo, B., Cross, N. L. and Liu, L. (2003) Fusion of lamellar bodies with the plasma membrane is driven by the dual action of annexin II tetramer and arachidonic acid. J. Biol. Chem. 278:39675-39683.

Narasaraju, T. A., Jin, N., Chintagari, N. R., Chen, Z., Gou, D. M. and Liu, L. (2003) Protein nitration of rat lungs during hyperoxia, a possible role for myeloperoxidase. Am. J. Physiol. 285: L1037-L1045.

Gou, D. M., Jin, N. and Liu, L. (2003) Gene silencing in mammalian cells by PCR-based short hairpin RNA, FEBS Lett. 548:113-118.

Abonyo, B., Wang, P., Narasaraju T., Rowan, W. H., McMillian, D.H., Zimmerman, U.J. and Liu, L. (2003) Characterization of -soluble N-ethymaleimide-sensitive fusion attachment protein in alveolar type II cells: implications in lung surfactant secretion. Am. J. Respir. Mol Cell Biol. 29:273-282.

Sun, P., Wang, J., Mehta, P., Beckman, D. L. and Liu, L. (2003) Effect of nitric oxide on lung surfactant secretion. Exp Lung Res. 29: 1-12.

2002

Rowan, W. H., Sun, P. and Liu, L. (2002) Nitration of annexin II tetramer. Biochemistry 41: 1409-1420.

Liu, L. Enright, E., Sun P., Tsai, S. Y., Mehta, P. Beckman, D. L. and Terrian, D. M. (2002) Inactivation of annexin II tetramer by S-nitrosogluthione. Eur. J. Biochem. 269, 4277-4286.

2001

Seidel, E. R., Ragan, V. L. and Liu, L. (2001) Nitration of tyrosine residues by peroxynitrite inhibits the activity of ornithine decarboxylase. Life Sci. 68: 1477-1483.

2000

Singh, T. and Liu, L. (2000) Modification of cysteine residues by N-ethylmaleimide inhibits annexin II tetramer-mediated liposome aggregation. Arch. Biochem. Biophys.  381: 235-240.

Beckman, D. L., Mehta, P., Hanks, V., Rowan, W. H. and Liu, L. (2000) Effects of peroxynitrite on pulmonary edema and the oxidative state. Exp. Lung Res. 26: 349-359.